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pentobarbital will decrease the level or influence of doravirine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital decreases levels of elvitegravir/cobicistat/emtricitabine/tenofovir DF by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. May perhaps lead to lack of virologic reaction and attainable resist